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Although insulin suppresses both GAL and NPY expression, leptin strongly inhibits NPY gene expression and release, yet produces little or no change in basal GAL expression in the ARC and only a small suppression of GAL expression in the PVN
doi: 10.1105/tpc.105.039339 15 ZhangTLiuRZhengJWangZGaoTQinMet al
Clinical trial data from the STEP program showed that semaglutide 2.4mg weekly produced average weight loss of 14.9% of body weight over 68 weeks, compared to tirzepatide at 15mg which achieved approximately 22.5% in the SURMOUNT trials
Kan, M., Guo, G., Singh, B., Singh, V
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